豬寶仔
2023-3-14 13:28:30
What are the available solutions for cartilage injuries?
Current available solutions for cartilage injuries are pain management, reparative surgery or total knee replacement. The benchmark to treat cartilage injuries in the USA is microfracture, a marrow stimulation technique where tiny fractures are made at the subchondral bone, inducing bone marrow stem cells to home to the damaged site, stimulating repair. This technique is simple and cost effective but only fibrocartilage is regenerated. As fibrocartilage is not native to the knee joint, it breaks down in 2 years.
Our research in articular cartilage regeneration with stem cells has shown to regenerate hyaline cartilage while conventional treatments have only been able to regenerate fibrocartilage.
KLSMC
在動物研究中,與鑽孔相比,微骨折會產生骨折和壓實骨,並導致骨細胞壞死增加
In the animal studies, microfracture produced fractured and compacted bone and led to increased osteocyte necrosis compared with drilling.
深鑽孔(6 毫米)優於淺鑽孔(2 毫米)和 MFx,因為它可以增加軟骨下血腫,更容易進入骨髓間質,改善軟骨修復,增加礦化骨。
Deep drilling (6 mm) was superior to both shallow drilling (2 mm) and MFx in terms of increased subchondral hematoma with greater access to marrow stroma, improved cartilage repair, and increased mineralized bone.
然而,無論骨髓刺激技術如何,軟骨修復組織的整體質量都很差。 在對患有骨關節炎和軟骨缺損的人類患者進行 MFx 和/或鑽孔後修復組織的 2 項研究中,研究人員發現軟骨修復組織沒有達到正常透明關節軟骨的質量。
However, the overall quality of cartilage repair tissue was poor regardless of marrow stimulation technique. In 2 studies that investigated repair tissue after MFx and/or drilling in human patients with osteoarthritis and cartilage defects, the investigators found that cartilage repair tissue did not achieve the quality of normal hyaline articular cartilage.
原來2011年馬拉已經有哩樣治療Drilling+stem cell+HA
好似幾先進,小型MRI 專門照腳
條友斷過韌帶 之後傷軟骨 關節退化
我就係當年哩個時候傷軟骨