It’s Malone, according to Karikó, who has been overstating his accomplishments. There are “hundreds of scientists who contributed more to mRNA vaccines than he did.”
He was the first author on a 1989 paper demonstrating how RNA could be delivered into cells using lipids, which are basically tiny globules of fat, and a co-author on a 1990 Science paper showing that if you inject pure RNA or DNA into mouse muscle cells, it can lead to the transcription of new proteins. If the same approach worked for human cells, the latter paper said in its conclusion, this technology “may provide alternative approaches to vaccine development.”
These two studies do indeed represent seminal work in the field of gene transfer, according to Rein Verbeke, a postdoctoral fellow at Ghent University, in Belgium, and the lead author of a 2019 history of mRNA-vaccine development.
first author on a 1989 paper demonstrating how RNA could be delivered into cells using lipids, which are basically tiny globules of fat, and a co-author on a 1990 Science paper showing that if you inject pure RNA or DNA into mouse muscle cells, it can lead to the transcription of new proteins.
↑單係呢一段, 佢又係第一個, 佢又係用老鼠做過實驗, 咁你想叫佢做乜?
然後呢, 連果個Karikó都講佢唔係發明者 replied that she hadn’t told anyone that she is the inventor of mRNA vaccines and that “many many scientists” contributed to their success. “I have never claimed more than discovering a way to make RNA less inflammatory,”
成篇就係講佢1989年起左個頭之後已經去左私人市場,冇做學術研究,之後30年有人 pick it up當時算非常冷門既 idea做左好多 break through先制成今時今日既疫苗
1. 你講野其實係好有濃烈的左膠臭味, 一個發明者佢為錢貪財有道德缺失佢就唔係發明者, 從呢度我都閒到你個意思. 但我唔怪你, 你應該都係比人毒害.
2. 發明者佢地不嬲係咁, 不論Steve Job到Tesla, 甚至今日的Elon Musk. 都唔似係聖人, 咁係咪因為咁, 佢地就唔係發明者?
3. 你講「之後30年有人 pick it up當時算非常冷門」,呢句完全係想誤導,篇論文寫於1989年, 而Dr.Karikó 問大學要grant做研究係1990年, 1年後你都想唔比credit人, 係咪你要出完論文1個月後佢遞支復必泰比你, 你先叫佢做發明者? In 1990, while a research assistant professor at the University of Pennsylvania’s Perelman School of Medicine, Karikó submitted her first grant application in which she proposed to establish mRNA-based gene therapy.
4. 達文西佢無做到個實體出黎, 如果佢做左架直升機飛到, 你當唔當佢係? 屌你, 如果你肯花幾秒, 去search佢篇論文, 睇下佢abstract, 你都唔會咁戇鳩用達文西去做比喻 https://pubmed.ncbi.nlm.nih.gov/2762315/ We have developed an efficient and reproducible method for RNA transfection, using a synthetic cationic lipid, N-[1-(2,3-dioleyloxy)propyl]-N,N,N-trimethylammonium chloride (DOTMA), incorporated into a liposome (lipofectin). Transfection of 10 ng to 5 micrograms of Photinus pyralis luciferase mRNA synthesized in vitro into NIH 3T3 mouse cells yields a linear response of luciferase activity. The procedure can be used to efficiently transfect RNA into human, rat, mouse, Xenopus, and Drosophila cells.
Robert Malone已經羅左老鼠仔黎做左實驗啦, OK? 架直升機已經起左機,在你頭上霍霍霍轉緊, 你抬高頭望下, OK?
Rapid and efficient memory-type immune responses occur reliably in virtually all unvaccinated individuals who are exposed to SARS-CoV-2. The effectiveness of further boosting the immune response through vaccination is therefore highly doubtful. Vaccination may instead aggravate disease through antibody-dependent enhancement (ADE).
總結係, 打針唔單止無咩用, 而且仲會加劇ADE效應 https://zh.wikipedia.org/wiki/%E6%8A%97%E4%BD%93%E4%BE%9D%E8%B5%96%E5%A2%9E%E5%BC%BA%E4%BD%9C%E7%94%A8 一些次優的抗體(一般為可結合病毒的非中和抗體)與病毒結合後,不僅不能防止病毒侵入人體細胞,反而會增強病毒感染免疫細胞、促進病毒在體內的複製,惡化疾病的嚴重度或誘發更嚴重的額外徵候。
Discovery 1: SARS-CoV-2 spike protein circulates shortly after vaccination
This means that a) the immune system will attack those endothelial cells, and b) the circulating spike protein molecules will activate thrombocytes. Both effects will promote blood clotting. This explains the many clotting-related adverse events—stroke, heart attack, venous thrombosis—that are being reported after vaccination.
點解會有血栓? 呢度解釋係, 因為免疫系統同血小板反應, 令到人出現血栓
Discovery 2: Rapid, memory-type antibody response after vaccination
Overall, these findings indicate that our immune system efficiently recognizes SARS-CoV-2 as “known” even on first contact. Severe cases of the disease thus cannot be ascribed to lacking immunity. Instead, severe cases might very well be caused or aggravated by pre-existing immunity through antibody-dependent enhancement (ADE, see below).
The goal of the vaccination is to stimulate production of antibodies to SARS-CoV-2, but we now know that such antibodies can and will be rapidly generated by everyone upon the slightest viral challenge, even without vaccination.
疫苖目的係為左刺激抗體生產, 但原來我地本身已經會生, 而且生得夠. 理由就係
Severe lung infections always take many days to develop, which means that if the antibodies generated by the memory response are needed, they will arrive on time. Therefore, vaccination is unlikely to provide significant benefit with respect to the prevention of severe lung infection.
Discovery 4: Rapid increase of spike protein antibodies after the second injection of mRNA vaccines
The situation changes dramatically with the second injection. Then the spikes are produced and protrude into the bloodstream that is already swarming with both reactive lymphocytes and antibodies. The antibodies will cause the complement system [9,10] and also neutrophil granulocytes to attack the spike protein-bearing cells. The possible consequences of all-out self-attack by the immune system are frightening.
Overall, the antibody will then have enhanced the replication of the virus. Clinically, this antibody-dependent enhancement (ADE) can cause a hyperinflammatory response (a “cytokine storm”) that will amplify the damage to the lungs, liver and other organs of our body.
而且多抗體係無作用, 而且仲有害, 但對唔住, 字數已經唔夠, 我下一個reply再講.
:^(
MolaMolaMola
2021-8-24 15:54:05
Antibody-dependent enhancement of disease
Regardless, we should not assume that high antibody titres against SARS-CoV-2 will always improve the clinical outcome. With several virus families—in particular with Dengue virus, but also with coronaviruses—antibodies can aggravate rather than mitigate disease. This occurs because certain cells of the immune system take up antibody-tagged microbes and destroy them. If a virus particle to which antibodies have bound is taken up by such a cell, but it then manages to evade destruction, it may instead start to multiply within the cell.
簡單講, 抗體唔係多多益善. 佢一來會引起免疫系統反應攻擊返自己, 二來就係ADE.
Conclusion
The collective findings discussed above clearly show that the benefits of vaccination are highly doubtful. In contrast, the harm the vaccines do is very well substantiated, with more than 15.000 vaccination-associated deaths now documented in the EU drug adverse events database (EudraVigilance), and over 7.000 more deaths within the UK and the US [13].
「如果唔係上帝創造世人,咁你講邊個係?」
不過你既然咁想知我就幫幫你
https://www.google.com/amp/s/amp.theatlantic.com/amp/article/619734/
It’s Malone, according to Karikó, who has been overstating his accomplishments. There are “hundreds of scientists who contributed more to mRNA vaccines than he did.”