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Other authors on the study are Yuyang Lei and Zu-Yi Yuan of Jiaotong University in Xi’an, China; Cara R. Schiavon, Leonardo Andrade, and Gerald S. Shadel of Salk; Ming He, Hui Shen, Yichi Zhang, Yoshitake Cho, Mark Hepokoski, Jason X.-J. Yuan, Atul Malhotra, Jin Zhang of the University of California San Diego; Lili Chen, Qian Yin, Ting Lei, Hongliang Wang and Shengpeng Wang of Xi’an Jiatong University Health Science Center in Xi’an, China.
The research was supported by the National Institutes of Health, the National Natural Science Foundation of China, the Shaanxi Natural Science Fund, the National Key Research and Development Program, the First Affiliated Hospital of Xi’an Jiaotong University; and Xi’an Jiaotong University.
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The research was supported by the National Institutes of Health, the National Natural Science Foundation of China, the Shaanxi Natural Science Fund, the National Key Research and Development Program, the First Affiliated Hospital of Xi’an Jiaotong University; and Xi’an Jiaotong University.
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上周五刊載於《循環研究》期刊，科學家證明新冠肺炎並非呼吸道疾病，而是一種血管疾病，解釋了為何有患者染疫後，會出現中風等呼吸系統以外的病徵，有關研究也詳細解釋棘突蛋白破壞血管細胞的機制，印證了之前有科學家對這種蛋白會損傷血管內皮細胞的懷疑。
科研人員在實驗室創造了一種滿布新冠病毒表面棘突蛋白，但內裡卻沒有任何病毒的「偽病毒」，然後暴露於動物模型，發現牠們肺部和動脈受損，組織樣本顯示肺動脈壁內層的內皮細胞發炎，足以證明單純棘突蛋白已可引起疾病。隨後團隊重複上述步驟，將健康的血管內皮細胞暴露於棘突蛋白，發現該蛋白當與ACE2受體結合時，破壞了ACE2對線粒體(為細胞產生能量的細胞器)的分子信號傳導，從而導致線粒體被破壞。
參與研究、助理研究教授Uri Manor表示，「如果去除病毒的複製能力，僅憑其與這種ACE2受體的結合能力，足以對血管細胞具有重大的破壞作用。」研究人員接下來希望深入研究這種破壞機制，為開發更有效治療提供了方向。
(來源：索爾克生物研究所)
網址：https://www.salk.edu/news-release/the-novel-coronavirus-spike-protein-plays-additional-key-role-in-illness/