由於啲research好散修修，直接post個review literature畀大家參考下 Results: A total of 33 articles including 28 topical finasteride related articles and five AGA related articles were included in this review. Multiple studies on topical finasteride as the treatment for male AGA and FPHL showed positive results with a favorable safety profile.
Conclusions: Topical finasteride is a promising therapeutic option. We emphasize the importance of continued research for the establishment of a novel therapeutic agent.
Poonkiat Suchonwanit, Wimolsiri Iamsumang & Kanchana Leerunyakul (2020): Topical finasteride for the treatment of male androgenetic alopecia and female pattern hair loss: a review of the current literature, Journal of Dermatological Treatment, DOI: https://doi.org/10.1080/09546634.2020.1782324
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至於Topical finasteride有咩特別好講呢?
最特別應該係依期一間叫Almirall嘅西班牙公司將Topical finasteride申請咗EMA Finasteride and Terbinafine were both submitted to the EMA: Finasteride (ALM12845) is a cutaneous spray solution demonstrated to be safe and effective in the treatment of androgenic alopecia, while Terbinafine (ALM12834) is indicated for the topical treatment of onychomycosis. https://www.almirall.com/newsroom/news/almirall-9m-2019-business-results
而佢哋嘅數據聲稱效果比得上Oral finasteride
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不過我見有唔少人質疑，因為Oral finasteride都要一段時間先降低到體內DHT濃度，Topical finasteride有冇可能咁快有效果?
另外佢哋聲稱唔見有嚴重副作用係安全產品，不過從以住大型finasteride數據上嚟睇，Oral finasteride都一樣係安全。所以消費者真正想知應該係Oral同Topical分別點影響頭皮DHT濃度同血液DHT濃度先係重點，但唔見有數據同時量度兩者比較。 https://clinicaltrials.gov/ct2/show/results/NCT03004469
Caserini, M., Radicioni, M., Leuratti, C., Terragni, E., Iorizzo, M., & Palmieri, R. (2016). Effects of a novel finasteride 0.25% topical solution on scalp and serum dihydrotestosterone in healthy men with androgenetic alopecia. International journal of clinical pharmacology and therapeutics, 54(1), 19–27. https://doi.org/10.5414/CP202467
師兄想問下,一個月買野搽大慨用幾錢?